Ozempic. Who is on it?

[FLAME ENVY]

Originally Posted by Johnny199r

Question:

For those of you with weight issues, how hardcore were you with eating properly/exercising at times and what if any success did you see as a result?

I was overweight up to a couple of years ago. I sold my car, moved to a central neighbourhood and now walk and cycle everywhere. I go to the gym regularly. I stopped snacking, I eat healthy, and do not eat after 6pm.

I've gone down from about 230 to 185 lbs and aside from a bum knee that won't let me take up jogging, I'm in great physical shape.

I listen to interviews from people who say "no matter what I did, I just couldn't lose weight, or keep it off, people just can't understand". As someone who used to overeat every single day, my change just came down to having ironclad willpower and saying enough is enough and adopting a massively healthy lifestyle. Did I want to eat junk or overeat for the longest time? Sure, but I didn't. Aside from having a thyroid issue, would that not be a successful recipe for weight loss for 99.9% of people?

You don't want to be a jogger anyhow, being a runner is far more meaningful!

[TorqueDog]

Originally Posted by afc wimbledon

I also wonder if the efficacy of the drugs will drop of some when they are cheaper and easy to access, I think to some degree the shear cost of the drug encouraged me to put some work into losing weight, I know I was thinking 'if I'm going to drop $400 on this I want it to work'

That would only be the case if the medications weren't so damned good at what they do with altering satiety signaling and food noise. This is especially the case with tirzepatide, and retatrutide even moreso being a triple agonist.

Unless you are a weak responder early on, or actively and consciously fighting against the appetite suppression and forcing yourself to gorge on calorically dense junk (think drinking melted ice cream -- Bill Burr has a bit about this), I think most people are going to have a hard time out-eating the direct pharmacological effects of these dual and triple agonist versions. Even with a lazy approach, the chemistry is stacked in their favour.

[Titan2]

Originally Posted by TorqueDog

Pretty much everything is more effective than semaglutide, and with less unpleasant side effects.

Retatrutide being the most promising one for sheer efficacy, though some mild but occasionally annoying side effects in some people that can be addressed with vitamin / mineral supplementation and extra intake of electrolytes. Survodutide, mazdutide, and pemvidutide are still early in their development and trial phases, but they're just dual agonists (GLP-1 and GCGR in place of GIPR).

How do you know so much about this? I did not think you were one of the pill-pushers or quacks on this site. Clearly, you have a detailed understanding.

[Titan2]

Originally Posted by Shazam

Username checks out?

Uhh, it says Receiver.

[TorqueDog]

Originally Posted by Titan2

How do you know so much about this? I did not think you were one of the pill-pushers or quacks on this site. Clearly, you have a detailed understanding.

I’m neither of those things, definitely a bit of a nerd and I’ve always found delving into epidemiological research interesting. I like reading sh-t on PubMed; it’s a weird passtime to have, I know.

My mom’s side of the family are all generally “bigger” people, and so this sudden surge in GLP-1 meds is drawing a bit more of my attention for how much it could help them and people like them. It’s also really fecking cool how they work, it’s just plain cool science. They don’t just change how people eat, they seem to reshape how the brain handles pleasure and reward too. Some patients report dropping other addictions like pop, alcohol, nicotine, and even cocaine while on them. No quackery about it, it’s like full-blown neurochemistry rewriting behaviour.

[Buff]

Originally Posted by dissentowner

Just got prescribed it for my recently diagnosed type 2 diabetes. Going to start it Saturday. Anyone taking it and what side effects have you had if any?

Welcome to the world of diabetes. I hope you manage it well and are able to continue managing it well. I was diagnosed 13 years ago... in two weeks it will be the official day of "yup, you have type 2 diabetes"

Initially I managed it like a champion. I completely changed my diet and I found a great workout program that kept my body strong and my A1C low. At that time I don't think Ozempic was a thing. I was prescribed Metformin.

Diet, pills and exercise. It worked for me and it was easy. Too easy. I started to have many cheat meals/days and it was easy to get back on track and quickly.

Cheat meals and days turned into cheat weeks and months and now I'm struggling to eat properly and as a result my A1C is not desirable. Not terrible like when I was first diagnosed but it needs to get better.

Makes me wonder if my doctor may switch me to Ozempic or some other new drug one of these years. I can stand to lose a bit of weight too. At one point I was 275lbs and I got sick and lost 40lbs but got back up to 250. Found myself in a weight loss challenge at work... My fairly fit 185 lb boss wanted a challenge to lose weight so he challenged me and the other guy in our department and he was about 330lbs. I won. I got down to 230, the other guy got down to 328 and the boss got down to 180. When I joined the diabetes club I got down to 205. I looked and felt great and I was a faster skater than I could ever imagine. I slowly crept back up to 225 and have been constantly there for about 4 years.

Maybe I ask my doctor about Ozempic? I need to try something to get my A1C at healthier levels and lose weight too.

[afc wimbledon]

Originally Posted by TorqueDog

I’m neither of those things, definitely a bit of a nerd and I’ve always found delving into epidemiological research interesting. I like reading sh-t on PubMed; it’s a weird passtime to have, I know.

My mom’s side of the family are all generally “bigger” people, and so this sudden surge in GLP-1 meds is drawing a bit more of my attention for how much it could help them and people like them. It’s also really fecking cool how they work, it’s just plain cool science. They don’t just change how people eat, they seem to reshape how the brain handles pleasure and reward too. Some patients report dropping other addictions like pop, alcohol, nicotine, and even cocaine while on them. No quackery about it, it’s like full-blown neurochemistry rewriting behaviour.

This is the part that really interests me frankly, when my dr suggested the jab I wanted to see what it felt like to be honest as I am sure this is some part of the future of addictions treatment