Ozempic. Who is on it?

[WideReceiver]

Originally Posted by Shazam

They say for every ten lbs lost you gain 1/2 inch of penis length.

What about girth?
-Women everywhere

[Winsor_Pilates]

Originally Posted by Sled

Not true! Myself and several people I have shared with and shared with me have lost 100lbs + and never looked back after being off it.

You are correct in that if you don't address the issues then yes you are going to continue treating a symptom not curing the cause.

We all know big pharma likes treating symptoms not curing so the skepticism is warranted.

Research shows you are in the minority, though it's new and not a lot of good studies yet.

The risk is that it's creating a calorie reduction by suppressing your appetite but not everyone will be able to keep their calories low once the suppression by drug is removed.
Additionally, your metabolic rate decreases as you get lighter, so your body will be able to use less calories and excess that cause fat gain will come at a lower number.
Particularly if people haven't put on muscle mass and learned meaningful lifestyle changes to keep them burning higher calories effectively post drug use.

Especially in America where the average diet is so bad, I suspect most people would go back to overeating calories if they do off the drugs.
Be proud you haven't.

[PaperBagger'14]

Originally Posted by Winsor_Pilates

The vast majority of calories a person burns are through regular old daily movements (NEAT). People underestimate them and overestimate the effect of cardio.
People also tend to eat back what they burn through cardio since they feel they earned it and get hunger spikes from the workout.

These drugs seem to be helping a lot of people, which is great.
I just hope the people who use them for weight loss create new habits that will help them keep it off after the drug use is gone.
It sounds like a few people in here have really done that which is awesome.

My father in law is on one of them and diabetic. He has lost a lot of weight and no side effects I'm aware of.

The calories in vs calories out as well as learning your “maintenance” caloric needs is so very important. Take for example the average calories burned during a marathon vs ingested in one meal at five guys:

Marathon - 2400 to 3600 calories
Five guys single bacon cheeseburger, small fry and peanut butter milkshake ~ 2300 calories

While training for distance running is awesome, you won’t lose weight doing it if you have a poor diet.

That’s an aside though, the success stories about weight loss (and keeping it off) are great to hear. Way to go.

[dissentowner]

Thanks everyone for the discussion. Good information shared.

[The Fisher Account]

Are these drugs all injections or can you take them in pill form now?

[Galakanokis]

I was on it for 8 months or so. 6'2" around 330lbs. Dropped about 70lbs but it was expensive to continue. New job since then and it should be covered again so thinking about going back on it. Outside of feeling a little nauseous when eating I had no other issues with. Lots of water and high protein for diet because you just don't eat as much. I have been off of it for 6 months or so and probably put 10-15lbs back on. Late night stress/boredom eating now though.

For me it was my knees. Both are severely arthritic and need to be replaced but I am a little to young to do it know so the doctors are trying to extend how long I can go before the replacement. Losing the weight rapidly was definitely nice. Knees do feel better and it made physio easier to do for sure.

[TorqueDog]

Originally Posted by Bill Bumface

Don't kid yourself, the driver for this wasn't Denmark. It was the $8B and growing revenue they have in the US now.

First approval was in the US as well. Just because there are foreign companies that make drugs the US market and approval processes are driving the bus for global pharma.

Yeah, I just thought it was funnier to link it to somehow protecting the long-term interests of the Danish chocolate industry by keeping T2D at bay.

Originally Posted by The Fisher Account

Are these drugs all injections or can you take them in pill form now?

Only Ozempic (semaglutide) has an oral variant -- called Rybelsus -- and there isn't technically an oral Wegovy equivalent. This may sound counterintuitive since they're literally all semaglutide under the hood, but it's the dosing regimen that makes Ozempic and Rybelsus approved for T2D, and Wegovy approved for obesity. Bioavailability of oral semaglutide is ~1%, meaning the maximum dose of Rybelsus (14mg/day) is the equivalent of about half the maximum dosage of Ozempic (2mg/week, so 1mg). So you need a much higher dose for lesser results, and it needs to be taken daily. Or you could just do a once-a-week tiny-ass pen needle or insulin pin.

Mounjaro/Zepbound does not have an approved oral version. The oral version of Ozempic uses an absorption enhancer called SNAC (heh) which is Novo's own IP, but Mounjaro is developed by Lilly and I don't see any way Lilly pays to license the tech from Novo.

[Mean Mr. Mustard]

Originally Posted by Winsor_Pilates

The vast majority of calories a person burns are through regular old daily movements (NEAT). People underestimate them and overestimate the effect of cardio.

I could be wrong but most of what you burn in calories are the activities not associated with movement but rather your basic metabolic rate which is associated predominantly with the activities that keep you alive. Then there is a sizable amount of calories dedicated to the digestion of food and the storage of energy. After that there are calories burned through movement.

That isn't to say that it isn't significant but I want to dispel the notion that people are fat because of laziness but rather because of complex multifactorial reasons both societal, psychological and physiological.

Exercise and movement is very important but it isn't the key to weight loss as it is near impossible to outrun a crappy diet.

[Johnny199r]

Question:

For those of you with weight issues, how hardcore were you with eating properly/exercising at times and what if any success did you see as a result?

I was overweight up to a couple of years ago. I sold my car, moved to a central neighbourhood and now walk and cycle everywhere. I go to the gym regularly. I stopped snacking, I eat healthy, and do not eat after 6pm.

I've gone down from about 230 to 185 lbs and aside from a bum knee that won't let me take up jogging, I'm in great physical shape.

I listen to interviews from people who say "no matter what I did, I just couldn't lose weight, or keep it off, people just can't understand". As someone who used to overeat every single day, my change just came down to having ironclad willpower and saying enough is enough and adopting a massively healthy lifestyle. Did I want to eat junk or overeat for the longest time? Sure, but I didn't. Aside from having a thyroid issue, would that not be a successful recipe for weight loss for 99.9% of people?

[afc wimbledon]

Originally Posted by Johnny199r

Question:

For those of you with weight issues, how hardcore were you with eating properly/exercising as times and what if any success did you see as a result?

I was overweight up to a couple of years ago. I sold my car, moved to a central neighbourhood and now walk and cycle everywhere. I go to the gym regularly. I stopped snacking, I eat healthy, and do not eat after 6pm.

I've gone down from about 230 to 185 lbs and aside from a bum knee that won't let me take up jogging, I'm in great physical shape.

I listen to interviews from people who say "no matter what I did, I just couldn't lose weight, or keep it off, people just can't understand". As someone who used to overeat every single day, my change just came down to having ironclad willpower and saying enough is enough and adopting a massively healthy lifestyle. Did I want to eat junk or overeat for the longest time? Sure, but I didn't. Aside from having a thyroid issue, would that not be a successful recipe for weight loss for 99.9% of people?

yes of course but who cares, if the drugs work why does it matter? it's not a moral test, no one 'needs' a nicotine patch or a Tylenol for a headache

[dissentowner]

Originally Posted by Johnny199r

Question:

For those of you with weight issues, how hardcore were you with eating properly/exercising at times and what if any success did you see as a result?

I was overweight up to a couple of years ago. I sold my car, moved to a central neighbourhood and now walk and cycle everywhere. I go to the gym regularly. I stopped snacking, I eat healthy, and do not eat after 6pm.

I've gone down from about 230 to 185 lbs and aside from a bum knee that won't let me take up jogging, I'm in great physical shape.

I listen to interviews from people who say "no matter what I did, I just couldn't lose weight, or keep it off, people just can't understand". As someone who used to overeat every single day, my change just came down to having ironclad willpower and saying enough is enough and adopting a massively healthy lifestyle. Did I want to eat junk or overeat for the longest time? Sure, but I didn't. Aside from having a thyroid issue, would that not be a successful recipe for weight loss for 99.9% of people?

That's great. Unfortunately most overweight people do not have that type of willpower.

[Mean Mr. Mustard]

Originally Posted by Johnny199r

Question:

For those of you with weight issues, how hardcore were you with eating properly/exercising at times and what if any success did you see as a result?

I was overweight up to a couple of years ago. I sold my car, moved to a central neighbourhood and now walk and cycle everywhere. I go to the gym regularly. I stopped snacking, I eat healthy, and do not eat after 6pm.

I've gone down from about 230 to 185 lbs and aside from a bum knee that won't let me take up jogging, I'm in great physical shape.

I listen to interviews from people who say "no matter what I did, I just couldn't lose weight, or keep it off, people just can't understand". As someone who used to overeat every single day, my change just came down to having ironclad willpower and saying enough is enough and adopting a massively healthy lifestyle. Did I want to eat junk or overeat for the longest time? Sure, but I didn't. Aside from having a thyroid issue, would that not be a successful recipe for weight loss for 99.9% of people?

Okay, that is great. I am happy for you. It sounds like you have found something that works for you and your lifestyle and that is awesome and you should feel proud of making changes that have benefited your health.

That being said, lots of people struggle with food and this approach of essentially shaming people for not having your willpower makes you come across as a judgmental ass.

[Mean Mr. Mustard]

Originally Posted by dissentowner

That's great. Unfortunately most overweight people do not have that type of willpower.

It isn't about willpower. If it was just an issue of willpower it would be a relatively simple thing. It is about societal issues, stressors, lifestyles, food insecurity, genetics/biological issues, mental health among other factors. There is a reason why obesity is a huge concern in every developed nation. It isn't willpower (which implies laziness) it is about giving people a tool to assist them in having a healthier lifestyle.

It feels akin to saying why do people take antidepressants - they should just try harder to be happy?

[Johnny199r]

The point of my post wasn't to shame anyone or boast. Use Ozempic or don't use it, to get where you need to go on your health journey.

My question was, are the people who say it's impossible to lose the weight or keep it off, being accurate with their statement, absent a thyroid issue? It's frustrating to cut through the hyperbole with some people in that situation. There's a decent amount of people out there who shout that it's an almost scientific impossibility for them to lose weight and or keep it off, which I don't agree with. Difficult? Sure. Lifestyle issues, injuries, lack of free time even poverty all contributing? Absolutely. But some sort of vague medical impossibility? I don't buy it.

[Johnny199r]

Originally Posted by Mean Mr. Mustard

It isn't about willpower. If it was just an issue of willpower it would be a relatively simple thing. It is about societal issues, stressors, lifestyles, food insecurity, genetics/biological issues, mental health among other factors. There is a reason why obesity is a huge concern in every developed nation. It isn't willpower (which implies laziness) it is about giving people a tool to assist them in having a healthier lifestyle.

It feels akin to saying why do people take antidepressants - they should just try harder to be happy?

I think as you get older, fitness or weight gain or health or whatever you want to classify it as, as our metabolism slows is about 80% diet (at least) and 20% fitness/activeness.

If two people smoke, and live pretty similar lives and one stops cold turkey and the other doesn't because they say they can't are you saying it doesn't come down to will power? even if those factors are present for both people?

If someone starts eating very clean tomorrow (water with every meal, brown rice and beans for supper, maybe some ground chicken, greek yogurt and banana for breakfast etc) and cuts out the junk food, regardless of their activity level, they'll lose weight. Yes they can have stressors in their life, yes they can have crappy genetics, yes they may drive to work every day 30 minutes each way, but won't this solve a lot of their problems and be within their control? It may not always be enjoyable, or fun, but isn't it doable?

[fotze2]

The title of the thread is about ozempic use not “I want to lose weight”. Everyone on the planet over 1 year old knows exercise and diet are awesome. Thanks for the revelatory knowledge fellas. Your lame anecdote about walking more is for the thread you create about walking more.

[curves2000]

Well to tie Ozempic, weight loss and health benefits all together, it is interesting that when people really do lose weight, they have healthier outcomes. It's the weight loss and perhaps a reduction in eating that is causing the health improvements, which goes to show you that we have been treating obesity and diabetes in the wrong fashion.

A LOT of people on Ozempic and other such drugs have become extremely frustrated with their lack of progress in weight loss and health improvements as a result if being on this medication. This medication is 100% suppose to be used in conjunction with strong healthy diet and exercise/activity and if you don't subscribe to that, then what do you actually want? This is why people have to up their dose and add more medication in order to hit their A1C target rate amongst other numbers. These medications are not magic.