Ozempic. Who is on it?

[WideReceiver]

Originally Posted by Shazam

They say for every ten lbs lost you gain 1/2 inch of penis length.

What about girth?
-Women everywhere

[Winsor_Pilates]

Originally Posted by Sled

Not true! Myself and several people I have shared with and shared with me have lost 100lbs + and never looked back after being off it.

You are correct in that if you don't address the issues then yes you are going to continue treating a symptom not curing the cause.

We all know big pharma likes treating symptoms not curing so the skepticism is warranted.

Research shows you are in the minority, though it's new and not a lot of good studies yet.

The risk is that it's creating a calorie reduction by suppressing your appetite but not everyone will be able to keep their calories low once the suppression by drug is removed.
Additionally, your metabolic rate decreases as you get lighter, so your body will be able to use less calories and excess that cause fat gain will come at a lower number.
Particularly if people haven't put on muscle mass and learned meaningful lifestyle changes to keep them burning higher calories effectively post drug use.

Especially in America where the average diet is so bad, I suspect most people would go back to overeating calories if they do off the drugs.
Be proud you haven't.

[PaperBagger'14]

Originally Posted by Winsor_Pilates

The vast majority of calories a person burns are through regular old daily movements (NEAT). People underestimate them and overestimate the effect of cardio.
People also tend to eat back what they burn through cardio since they feel they earned it and get hunger spikes from the workout.

These drugs seem to be helping a lot of people, which is great.
I just hope the people who use them for weight loss create new habits that will help them keep it off after the drug use is gone.
It sounds like a few people in here have really done that which is awesome.

My father in law is on one of them and diabetic. He has lost a lot of weight and no side effects I'm aware of.

The calories in vs calories out as well as learning your “maintenance” caloric needs is so very important. Take for example the average calories burned during a marathon vs ingested in one meal at five guys:

Marathon - 2400 to 3600 calories
Five guys single bacon cheeseburger, small fry and peanut butter milkshake ~ 2300 calories

While training for distance running is awesome, you won’t lose weight doing it if you have a poor diet.

That’s an aside though, the success stories about weight loss (and keeping it off) are great to hear. Way to go.

[dissentowner]

Thanks everyone for the discussion. Good information shared.

[The Fisher Account]

Are these drugs all injections or can you take them in pill form now?

[Galakanokis]

I was on it for 8 months or so. 6'2" around 330lbs. Dropped about 70lbs but it was expensive to continue. New job since then and it should be covered again so thinking about going back on it. Outside of feeling a little nauseous when eating I had no other issues with. Lots of water and high protein for diet because you just don't eat as much. I have been off of it for 6 months or so and probably put 10-15lbs back on. Late night stress/boredom eating now though.

For me it was my knees. Both are severely arthritic and need to be replaced but I am a little to young to do it know so the doctors are trying to extend how long I can go before the replacement. Losing the weight rapidly was definitely nice. Knees do feel better and it made physio easier to do for sure.

[TorqueDog]

Originally Posted by Bill Bumface

Don't kid yourself, the driver for this wasn't Denmark. It was the $8B and growing revenue they have in the US now.

First approval was in the US as well. Just because there are foreign companies that make drugs the US market and approval processes are driving the bus for global pharma.

Yeah, I just thought it was funnier to link it to somehow protecting the long-term interests of the Danish chocolate industry by keeping T2D at bay.

Originally Posted by The Fisher Account

Are these drugs all injections or can you take them in pill form now?

Only Ozempic (semaglutide) has an oral variant -- called Rybelsus -- and there isn't technically an oral Wegovy equivalent. This may sound counterintuitive since they're literally all semaglutide under the hood, but it's the dosing regimen that makes Ozempic and Rybelsus approved for T2D, and Wegovy approved for obesity. Bioavailability of oral semaglutide is ~1%, meaning the maximum dose of Rybelsus (14mg/day) is the equivalent of about half the maximum dosage of Ozempic (2mg/week, so 1mg). So you need a much higher dose for lesser results, and it needs to be taken daily. Or you could just do a once-a-week tiny-ass pen needle or insulin pin.

Mounjaro/Zepbound does not have an approved oral version. The oral version of Ozempic uses an absorption enhancer called SNAC (heh) which is Novo's own IP, but Mounjaro is developed by Lilly and I don't see any way Lilly pays to license the tech from Novo.

[Mean Mr. Mustard]

Originally Posted by Winsor_Pilates

The vast majority of calories a person burns are through regular old daily movements (NEAT). People underestimate them and overestimate the effect of cardio.

I could be wrong but most of what you burn in calories are the activities not associated with movement but rather your basic metabolic rate which is associated predominantly with the activities that keep you alive. Then there is a sizable amount of calories dedicated to the digestion of food and the storage of energy. After that there are calories burned through movement.

That isn't to say that it isn't significant but I want to dispel the notion that people are fat because of laziness but rather because of complex multifactorial reasons both societal, psychological and physiological.

Exercise and movement is very important but it isn't the key to weight loss as it is near impossible to outrun a crappy diet.

[Johnny199r]

Question:

For those of you with weight issues, how hardcore were you with eating properly/exercising as times and what if any success did you see as a result?

I was overweight up to a couple of years ago. I sold my car, moved to a central neighbourhood and now walk and cycle everywhere. I go to the gym regularly. I stopped snacking, I eat healthy, and do not eat after 6pm.

I've gone down from about 230 to 185 lbs and aside from a bum knee that won't let me take up jogging, I'm in great physical shape.

I listen to interviews from people who say "no matter what I did, I just couldn't lose weight, or keep it off, people just can't understand". As someone who used to overeat every single day, my change just came down to having ironclad willpower and saying enough is enough and adopting a massively healthy lifestyle. Did I want to eat junk or overeat for the longest time? Sure, but I didn't. Aside from having a thyroid issue, would that not be a successful recipe for weight loss for 99.9% of people?