Couple of threads to check out:
http://forum.calgarypuck.com/showthread.php?t=105946
http://forum.calgarypuck.com/showthread.php?t=129630
http://forum.calgarypuck.com/showthread.php?t=110697
Are you going south from SF? We went south (from SF to LA) on the 101 through Big Sur. Stayed overnight in Cambria, visited Hearst Castle. Heard the Oregon Coast is nice but can't speak from personal experience (just stayed on I-5; we were heading south).
My tip - depending on how much time you have (and how much you like SF), I would spend as much time in places accessible by road only (i.e. on the 101, especially if you decide to go up north through Oregon). A future trip back to SF is only a plane ride away, but to get to the Oregon Coast or along the Pacific Coast Highway will be a lot harder to schedule for the second time around.