Many email clients enforce plain text. That gets rid of all the formatting you put in place (other than line breaks).
Nothing you can do about it - it is a setting on their side; either their email system or client.
The reason you see the setting are greyed out is because Outlook realizes their response was plain text. You can re-enable those settings by changing to Rick Text Formatting (RTF) or HTML, but if they have their account and/or client set to plain text, your special formatting will disappear.
There is an argument out there that all email should only be plain text. That removes some of the many virus possibilities that have existed in the past. If your email client can act like a web browser then it must get all the same patches as a web browser. By enforcing plain text then that prevents any malicious code from ever possibly happening.
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