QTEs were fun when they first came out back in the Dreamcast days since it was something new and fun to pull off. Then it got stale when many games began doing it and gamers like me wanted to put down their controllers to watch cutscenes, only to realize that the character was going to have to perform some action or die. So instead of sitting back and watching the cutscene with beer/joint in hand, I had to sit in the ready position holding my controller waiting to do something.
Some games do it nicely, like the Walking Dead games where it's actually part of the action and there are different QTE movements. I found them in E33 to be pretty stale. Just press A once or twice at a certain point on the outline of the box. I just started act 2, so unless there is some other kind of cool mechanic I have yet to see, it's the same thing repeatedly.
I personally would rather just turn them off, sit back and watch the cutscene. Then again, E33 also forces me to press A to advance the dialogue during some scenes which also somewhat ruins the flow, so I guess I'm stuck holding my controller regardless