Toronto has an overwhelming amount of fantastic food choices. Pick a country and find their neighborhood.
If you do go to burgers priest, my once per year burger from there is the Vaticanized Pope. Just eat nothing but salad the next day.
There is a good french restaurant near second city that you could take the wife to - Le Select.
If you have a group here, I would try an escape room near downsview station called escape games Canada. There are probably over 40 escape room companies in the city, and the one at downsview has been the best that I have tried so far.
Definitely go to the distillery district at night for dinner! I like Cluny, but I'm sure you won't be disappointed.
Also, Toronto always has something going on somewhere. TIFF is going on now, but check to see if any festivals are happening while you are here.
http://m.toronto.com/things-to-do/