He had a great interview with Marc Maron on WTF a few months ago. Led a crazy life of a wannabe wise guy, consumed most of his product and ended up getting HIV but a really great story of turning his life around, meeting his wife and them dealing with their disease together and becoming a comedian.
Damn, I was familiar with his act. Caught him a couple years ago at the Beacon Theater in NYC, part of the NYC Comedy Fest and that particular night was hosted by Denis Leary.
Destephano was one of the best comics of the night, loved his set.
Opie & Anthony did a good 20 mins on Destephano yesterday for those who want to download it. Jim Norton knew him a bit and gave his impression of the guy, also played some clips of his last visit to the studio.