Chuck a humidifyer in there, that will keep the dust down. Newer cases may even have filters on the intakes. They aren't the best but they will catch some of it, clean them ever month or so. Also the obvious one, make sure your puter isn't sitting on carpet or directly on the floor, put it on a desk or at least a small stand to keep it a couple inches off the floor.
The humidifyer really does the trick though, I have TONS of electronics in one room in my basement, static electricity was my main concerns but it does keep the dust down.
Oh, and obviously stay on top of your furnace filters as well.
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Computer room dust
