Time for a bump for this thread after seeing one of the funniest movie trailers I can remember from the past couple of years today while at work. Hopefully they save some funny stuff for the actual movie, but Rainn Wilson looks to have picked the perfect role for his big screen comedy breakthrough performance:
http://movies.yahoo.com/movie/1809909025/video/7698125/
Edit- one more to add, the new film from David Fincher starring Brad Pitt in which the main character ages backwards. The trailer is crap quality, and in spanish, but is still awesome. Has a dreamy, odd effect partly due to the editing and music. Fincher's movies are kickass, too bad we have to wait 6 months to see this one.
http://www.youtube.com/watch?v=PqvVD6HQqyM