I use to drive straight through but I travelled at night to avoid the traffic and make better time. It never bothered me if it was winter or not, just drive a little more carefully and if the Coc is bad just take the canyon (#1).
My worst experience was a snow slide coming down in front of me, causing me to get a motel in Golden for the night and than having to detour south to get around it. Be flexible and stop for the night if needed or detour if needed and you should be fine.
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