Jane Lynch is a bit too acerbic for Egon and I don't think I have seen her play a comedic role where she wasn't like that. Not that it matters if it's truly a reboot, and not trying to run parallel with the original cast and story. Anyway, if the case is for some similarities, I might opt for Geena Davis. She has good comedic talent and could play the part and portray a tall, nerdy, scientist type.
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