The Gears campaign is playable without any prior knowledge, but it's always better to have some.
I'm a huge fan of the series. Played through them all just a couple years ago for the first time. The newest game really brings the series into a whole new stratosphere. The RPG elements (similar to God of War), the stunning graphics and the depth of the story really shine through.
I am super happy with the game so far & can't wait to sink in an abundance of time into the game