A sample size of 8 also really limits the above preprint study's predictive power.
Quote:
428 Rhesus macaque model and immunizations
All experiments conducted according to NIH regulations and standards on the humane care and use of laboratory animals as well as the Animal Care and Use Committees of the NIH Vaccine Research Center and BIOQUAL, Inc. (Rockville, Maryland). All studies were conducted at BIOQUAL, Inc. Four- to eight-year-old rhesus macaques of Indian origin were stratified into groups based on sex, age and weight. Eight macaques were immunized with mRNA-1273 at weeks 0 and 4 with a dose of 100μg delivered intramuscularly in 1mL of formulated lipid nanoparticles diluted in phosphate-buffered saline (PBS) into the right quadricep as previously described (Corbett et al., 2020; Corbett et al., 2021c; Gagne et al., 2022). At week 41 (~9 months after the second immunization), the eight macaques were split into two groups of 4 and boosted with 50μg mRNA-1273 or 50μg of mRNA-Omicron. Animals in the control group were immunized with 50μg control mRNA at the time of the boost.
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-James
GO FLAMES GO.
Last edited by TorqueDog; 02-05-2022 at 11:14 AM.
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