1. Take the PCH/101 as much as humanly possible. One of the most beautiful drives anywhere in the world. My favorite sections are in Oregon, but the whole route is pretty nice. Stop at Cannon beach...if it looks familiar, its because that's where they filmed the Goonies. Multnomah Falls (more inland, closer to Portland) is beautiful too...it's along the way if you do Calgary > Portland.
2. Watch out for all the weirdo meth heads that permeate small-town America.
3. Stop to enjoy the red woods on the way.
4. Don't ever call it San Fran.
5. Calistoga is a great day/weekend trip in the Bay Area.
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