Probably more risk never opening and closing a valve. Stuff can build up, oxidation, etc and then when you really need it, it can break, or not operate at all. Probably less of an issue on newer ball valves. I had to have my ancient gate valve replaced because it leaked, and scared me every time I had to turn it. I guess if you have a tiny leak like a faucet drip, lines depressurize and it's always hardest on lines/joints during re-pressurization, particularly if you don't have water hammer aresstors(your newer build probably does). You can turn it on slower if that's a concern.
One issue is if you have hardwood floors and are gone for awhile your humidifier won't be working. Going to depend on the house if that's an issue. I also turn off my on demand water heater. Not sure it's necessary, but it's one button.
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