[TheIronMaiden]

Originally Posted by PepsiFree

What age would you allow puberty blockers for?

I think that questions is dependent entirely on the central question which is: What are the long term effects of puberty blockers and health and wellbeing?

for example

The synthesis of findings from multiple fields of study (neurodevelopment, neuroimaging, neuroendocrinology) indicates an association between GnRH expression and brain function and structure. Despite the broad and multidisciplinary knowledge base which indicates disruption of GnRH expression is likely to have an impact on cognitive function, and explicit calls in the literature for this to be studied that date back three decades,46 there have been no human studies to date that have systematically explored the impact of these treatments on neuropsychological function with an adequate baseline and follow-up.

While no means conclusive due to the poor quality of evidence, studies examining the impact of puberty suppression in young people indicate a possible detrimental impact on IQ.43, 48, 49 These findings accord with the wider literature on GnRH expression and brain structure and function. Studies in mice, sheep and primates indicate an impact of GnRH suppression on behavioural analogues of cognitive function, effects that are often sex specific. While there is some evidence that indicates pubertal suppression may impact cognitive function, there is no evidence to date to support the oft cited assertion that the effects of puberty blockers are fully reversible.51, 53 Indeed, the only study to date that has addressed this in sheep suggests that this is not the case.39

https://www.thelancet.com/journals/l...235-2/abstract