Been there, done that with Xenical - the prescription drug. Not the smartest move, but my doc suggested it. It was nasty to say the least. The one thing - it did get me eating much much much more in veggies and lean meat because fatty stuff was not pretty.
So if you want to lose weight by pure and utter fear of sh***ing your pants - that's the way to go. Otherwise, I'd go with the sensible eating route.