I wouldn't really include any bands that changed sound due to changes of significant members (Fleetwood Mac, AC/DC, Black Sabbath, Pink Floyd, Van Halen, etc.).
As mentioned above, Metallica changed a lot (not for the better IMO), same for Heart.
Suicidal Tendencies morphed quite a bit from pure punk to mostly metal.
Anyway, the answer is still probably Bowie.
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