I preface this by acknowledging I have only been to Florence + Area and Venice so I can't really compare it to other areas.
Florence is great and there are a ton of museums and surrounding towns to fill your time. For example, Siena and San Gimignano are great towns in the interior, with Cinque Terre near the coast.
We did a day trip from Florence to Venice and thought that was enough time, although I would like to spend the night in Venice and see it after most of the crowds are gone
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