I don't know about the "most disappointing" but I recently read "Children of Men" by PD James because I'd heard it was such a good movie. I still haven't seen the movie but the book was just plain awful. Awful enough to throw on the floor at the end of it.
"Mason and Dixon" by Thomas Pynchon was disappointing, I think. I had read a couple of his earlier books and liked them but I couldn't figure out where he was going with that one and it was so damn heavy (literally) I just gave up.
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