I don't know if it's fair to say that they had no chance until Lend-Lease support started coming in. The tide had already started to a turn a bit in 1942, which was before any real quantities of weapons/materials had arrived from the US. But it was absolutely vital to the effectiveness and speed of the Soviet Army and its war effort from 1943-1945. Without that support, it's pretty unlikely that the war would have ended as quickly as it did.
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