07-22-2022, 09:07 AM
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#3
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First Line Centre
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No pay wall here:
https://www.sciencedaily.com/release...0720080145.htm
Quote:
After decades of study, there remains no clear evidence that serotonin levels or serotonin activity are responsible for depression, according to a major review of prior research led by UCL scientists.
The new umbrella review -- an overview of existing meta-analyses and systematic reviews -- published in Molecular Psychiatry, suggests that depression is not likely caused by a chemical imbalance, and calls into question what antidepressants do. Most antidepressants are selective serotonin reuptake inhibitors (SSRIs), which were originally said to work by correcting abnormally low serotonin levels. There is no other accepted pharmacological mechanism by which antidepressants affect the symptoms of depression.
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