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Originally Posted by curves2000
Thank you for your very clear and well written response as this is helpful. The request for Novavax was for some friends so I will pass along the info and tell them to contact AHS and or the Health Ministry for more information.
Ironically I just came across this study on vaccine effectiveness and waning effectiveness that was published a week ago.
https://www.thelancet.com/journals/l...seccestitle130
I was wondering, if you had the time or the interest, to potential breakdown some of the finer points of the results? |
That looks like it largely agrees with the UK's other data. AZ seems to hold up pretty well in younger people, but struggles a bit more in the 50+ group at preventing infection. Though at this point a lot of that data is kind of out the window given Omicron's emergence. If you want more up to date data about waning (including protection against severe disease), the UK does publish weekly vaccine surveillance data with all that.
Here's the latest (relevant data starts on page 5). Basically all the vaccines are struggling after 2 doses to protect against Omicron, and even the booster eventually wanes (though people who received Moderna for the first 2 doses seem to be holding up better than the rest).
They no longer seem to break down the different vaccines against hospitalization, but they did up until a few weeks ago
; here's the latest (starting on page 9). 2 doses of either AZ or Pfizer was struggling at preventing severe outcomes, but 3rd doses restored protection (though a 3rd Pfizer dose did show signs of waning while Moderna didn't, at least yet).
The one caveat though, is that those numbers would include a lot of incidental hospitalizations; given the UK's extremely high vaccination rate among their older population, that would tend to underestimate vaccine effectiveness.
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If you don't mind, may I ask your background or interest in the vaccine or medical field? Along with a few other posters, you have been instrumental to providing a ton of quality information and analysis on the vaccine topics that have been discussed.
Thanks again!
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My work is sort of tangentially related to medical research. So part of my job is working with researchers and then synthesizing research/medical papers into broader/simpler language for other purposes (seeking funding for research, proposals, etc.).