Quote:
Originally Posted by opendoor
Canada has the Novavax doses, but it doesn't seem like provinces are doing a very good job of rolling them out, so they're kind of just sitting there.
As for AZ boosters, few (if any) places are using them as 3rd doses so there isn't much real world data. And while that study that AZ linked showed in increase in immune response with a 3rd dose, it was still inferior to basically every other option for a 3rd dose. Here's an image that shows the antibody and cellular response of people who've had 2 AZ doses and then got a 3rd dose of AZ, Novavax, Pfizer, Moderna, J&J, CureVac, or Valneva. So in terms of antibodies, Moderna is a best, followed by Pfizer. But Novavax is pretty good. And in terms of cellular response, Novavax is excellent (2nd behind Moderna for AZ recipients).
So if you're wanting to avoid mRNA vaccines for a 3rd dose, I'd try to see if you can get Novavax. The antibody response is quite good and the cellular response (even against variants) is basically as good as it gets. Whereas 3 doses of AZ doesn't look all that great. Adenovirus vaccines look like they can do a fantastic job of stimulating cellular immune response (which is important for protection against severe disease over the long term), but not on their own. They seem to really need to be part of a heterologous regime with a non-viral vector vaccine to achieve that excellent cellular response. |
Thank you for your very clear and well written response as this is helpful. The request for Novavax was for some friends so I will pass along the info and tell them to contact AHS and or the Health Ministry for more information.
Ironically I just came across this study on vaccine effectiveness and waning effectiveness that was published a week ago.
https://www.thelancet.com/journals/l...seccestitle130
I was wondering, if you had the time or the interest, to potential breakdown some of the finer points of the results?
If you don't mind, may I ask your background or interest in the vaccine or medical field? Along with a few other posters, you have been instrumental to providing a ton of quality information and analysis on the vaccine topics that have been discussed.
Thanks again!