Quote:
Originally Posted by GGG
Is the poor immunity of Omicron against older variants against infection or severe disease or both?
|
With how dominant Omicron is, there haven't really been enough Omicron recovered people who subsequently caught a non-Omicron variant to draw any conclusions about severe disease, but there likely would be some protection.
But against infection, even a recent Omicron recovery didn't produce antibodies capable of neutralizing Delta in most of cases that I've seen. This image illustrates it pretty well. On the right are unvaccinated people who caught Omicron and then had their blood tested for antibodies against Delta. Basically, the people who mounted any kind of real protective response against Delta were the people who already had antibodies at enrollment (i.e. a prior infection). The immunologically naive (with maybe 1 or 2 exceptions) failed to reach the threshold of protection against Delta:
