No one ever smoked a cigarette then beat their wife, or traumatized their family, or got in a car accident, or started a fight as a direct result of it.
If you want to evaluate substances based on harm done to others, Alcohol is in the lead by miles and miles.
e: I've been to music festivals where alcohol was the only banned substance, because of the profoundly toxic way it reacts to other substances and how it was by far the most harmful and destructive substance.
In this chart, Alcohol is comparable to Opiods & GHB (spoilered for size)