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Originally Posted by DeluxeMoustache
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Key findings and recommendations from the AHS doc
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KEY FINDINGS
• The studies evaluating ivermectin treatment are not high enough quality to
properly decide if ivermectin is useful or not. Most studies did not clearly describe the effect of the other medications given to patients or what other factors might influence their findings (“confounding”), did not have an adequate comparator group to assess if there was a difference in patients given ivermectin, or were too small to be sure that any effect of ivermectin seen was real.
• With respect to ivermectin's ability to prevent infection with COVID-19, four low quality studies showed that ivermectin may reduce the risk of COVID-19 infection; however, there were several confounding factors and we don’t know what else the study participants were doing that might have influenced their risk of infection. More studies are needed to show if ivermectin can be used to prevent infection.
• With respect to ivermectin's ability to treat people with COVID-19, seven studies that had a control group (ie. a group of participants that did not receive ivermectin) reported the effect of ivermectin on death from COVID-19. Four showed that deaths from COVID-19 went down, while three showed that deaths from COVID-19 were not affected. All seven studies were small and were of low or very low quality, so we can’t be sure that their findings were real. More studies are needed to show if ivermectin can be used to treat COVID-19.
• The available data on ivermectin purchasing in Alberta doesn’t clearly show us if it is being used for purposes other than parasitic infections (ie. for COVID-19).
RECOMMENDATIONS
• At this time, ivermectin should not be prescribed or taken to prevent COVID-19
outside of a clinical trial, as we need to establish whether it is truly useful.
• At this time, ivermectin should not be prescribed or taken to treat COVID-19 outside of a clinical trial, as we need to establish whether it is truly useful.
• Scientists in Alberta should support clinical trials of ivermectin to help clarify whether ivermectin is effective against COVID-19 or not.
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I wonder if this study is one of the main things that drove people’s interest
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• Ivermectin has been shown to inhibit viral replication in vitro, but at concentrations that may be unattainable with human therapeutic doses. Vero cells (a non-human cell line) infected with SARS-CoV-2 and treated with 5 μmol/L ivermectin at 2 hours post-infection showed a 5000X reduction in viral replication compared to untreated controls. However, the 100% inhibitory concentrations of ivermectin needed in vitro are approximately 50-55X higher than the maximum plasma concentration of ivermectin after an oral dose of 12 mg in adults
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