Dammit... started riding again 2-3x weekly after a few months off. Other than dealing with a couple health issues over the years (incl. a broken leg bone) I've not taken this much time off the bike in over 10 years. Last fall my seat was super comfy... but now it's not. After riding 2x/wkly for the last month my one side sit bone almost feel bone-bruised. Ouch. So I've now changed my saddle that doesn't look quite as good on the bike but hopefully won't aggravate until my poor bones and butski gets used to riding again.
Here's a good article on the subject:
https://www.cyclingnews.com/features/saddle-sores-101/