For example (before the Toltecs and Aztecs),
https://en.wikipedia.org/wiki/Teotihuacan
Quote:
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At its zenith, perhaps in the first half of the first millennium (1 CE to 500 CE), Teotihuacan was the largest city in the pre-Columbian Americas, with a population estimated at 125,000 or more, making it at least the sixth-largest city in the world during its epoch.
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