I think it all goes back to Nintendo, they really started the trend.
Quote:
The English manual for Super Mario Bros. 2 refers to Birdo as “a male who thinks he is a girl"[1] and would prefer to be called "Birdetta". Some take that as a representation of Birdo as transgender,[2][3][4] making her as the first transgender videogame character.
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https://en.wikipedia.org/wiki/Birdo
I'd absolutely be Fuzzette.