As some others have mentioned...if you have the desire/ability to sort through some of it (you'd need the instruction books to go with the sets, in the very least) you may be able to make some coin off of it.
If not, you can try to sell it via weight.
An option I've heard of in the past, though I've no idea of they are doing this now, is that you could donate it to the Children's Hospital.
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