I do, and it's great at times, but it's also nice to be able to go into the office when I want - mostly for being around people (and not just web conferencing).
The biggest downside is that your home no longer becomes your refuge, so it's up to you to determine your relationship with your home life. Personally I find myself going for more walks, coffees, and going to the gym more when I work at home.
Also, get yourself a good desk setup and and ergonomic chair - perhaps your company can help pitch for this?
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