[SportsJunky]

However, there’s another reason why people might feel anxious while stoned, even long after their first time. THC binds to the brain’s cannabinoid receptors, releasing the neurotransmitters dopamine, serotonin, and GABA, a neurotransmitter that stops neurons from firing, Giordano explains. Increased GABA and serotonin activity inhibits norepinephrine—a neurotransmitter involved in alertness and anxiety—which calms most people down.

But for some people, reduced norepinephrine has a rebound effect, stimulating activity in the brainstem’s locus ceruleus and limbic forebrain, which are involved in arousal and excitation, Giordano says. This activity in turn sends the sympathetic nervous system into overdrive, leading to a rise in heart rate and release of cortisol, which we tend to perceive as anxiety.

Gio does it all!