The Metropolitan Police said officers were called at 16:38 GMT to "a number of reports of shots fired" on Oxford Street and Oxford Circus Tube station.
"Police have responded as if the incident is terrorist related," a statement said.
"Armed and unarmed officers are on scene and dealing along with colleagues from British Transport Police.
"If you are on Oxford Street go into a building and stay inside until further direction. Avoid travelling to the Oxford Street area.
"At this stage police have not located any casualties."
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