Assuming you aren't the only voice on your podcast, I suggest using zencastr.com to record.
Recording over Skype usually ends up with one side of the audio being awful. Zencastr instead records each participant locally and then uploads the tracks as individual (but synced) files. Then you load them into your editor and merge them into one track. You can use built in VOIP or use Skype to hear the other participants - either way, the output is the same.
I use Audacity for editing, pretty easy usually.
Aside from that, make sure your mic is good. I suggest a Blue Snowball or Yeti, but I have a Nessie and like it quite a bit.
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Formerly CPHL - LA Kings
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