Quote:
Originally Posted by opendoor
My understanding is that on a per mg basis hydromorphone is about 3-4 times more potent than diamorphine.
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While technically true, the reason heroin is so addictive is that it is far more lipophilic and therefore reaches high concentrations in the brain much quicker and higher than equivalent doses of hydromorphone. Basically, while the conversion works for analgesic doses, the effective doses can be quite different