I have been to San Diego 3 times and it's a fantastic place to visit. Lots of solid advice in this thread. The only thing I have to add is to be aware of the wild temperature fluctuations between different parts of the SD area. It is always around 22C - 25C down by the ocean, but can shoot up to over 35C as you head further away from the water.
Assuming you are travelling from Calgary, try to get the direct flight. Going through LAX is a major pain and should be avoided if possible.
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