Well, that was damn entertaining flick to say the least. I'm not super well versed in the comics, but from the portion of Cable & Deadpool I've read, they nailed it. The wisecracking got a little repetitive at times, but it's on point with the character, and was witty for the most part.
One thing that kinda bothered me:
Overall it was a great flick however, I'm not sure how well it would hold up to repeat viewings, but Reynolds knocked it out of the park.