I have a signed white Cujo jersey that was getting a bit gringy around the seams (why does dirt only collect there?) It was signed with what looked to be a blue sharpie or signature pen.
After much thought, I handwashed it in cold water, then hung it up and let it dry. It was fine after that. There was a very slight amount of bleeding in the signature, but nothing too noticeable (it pretty much just softened the edges of the signature).
I was happy with that. There's no way that I'd toss it in a washing machine, though.
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