The perks you choose make a huge difference, as well. If you're having trouble killing things before you die, maybe pick a specific type of weapon Perk to use, (Commando, Gunslinger, Rifleman, Heavy Hitter, etc.)
If you just can't say alive, consider putting some points in Life Giver, or building up your Endurance a little bit. On my first play-through I maxed out Endurance and got Ghoulish and Solar Powered. I recommend avoiding Ghoulish, but Solar Powered was awesome.
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