Yeah, I would agree that there isn't going to be much in the way of changes to fundamental understandings of nature. The biggest thing would be to find life based on different conditions than our own, but the level of tech required to do that is currently out of our reach.
I do think that the "gadgets" will cause fundamental shifts in the way we interact and organize. Nanotech, computers in our brains, robotic limbs, 3-D printed organs. This stuff is going to revolutionize humanity, but not necessarily alter humanity's understanding of nature.
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