I've had good luck with combofix.
http://www.bleepingcomputer.com/download/combofix/
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ComboFix is a program, created by sUBs, that scans your computer for known malware, and when found, attempts to clean these infections automatically. In addition to being able to remove a large amount of the most common and current malware, ComboFix also displays a report that can be used by trained helpers to remove malware that is not automatically removed by the program.
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