I use avast with silent (Gaming) mode on. Seems to work fine and doesn't use too many resources. That coupled with adblock plus and a quick check via malwarebytes and Nod32 trial 2-3 times a year seems to work well for me. Noscript is great too, but then I have to go through the annoyance of individuals confused my "computer isn't working". So I stopped using it.
Avira and Panda are light weight as well, but I am not sure of their effectiveness. It seems the "best" program changes every few years. As someone has already mentioned, relying solely on one program isn't recommended anyways.
Now, one thing I have noticed... some programs (legit ones) have offers attached to them. Those are nasty programs and usually ones that are tool bars to browsers and whatnot. Some of them are pretty obvious with words like "Free, shopping, etc." Some of them are more confusing with names like conduit or X search engine and wording that almost makes you think it's necessary part of the program being installed. One even tried to mask itself as adobe flash!
Let's just say I know a bunch of individuals for whom I am more than happy to segregate them to their own computers and even with anti-virus, malware programs on it, they still find ways to install dumb things on the computer. It turns out, flash game sites and streaming sites for gossip girl are by far the worst offenders for putting crap on a machine.
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