How they go, which as suggested likely wont be the case in the show anyways, is probably the most important detail. Varys getting his hands dirty, especially to cause chaos for Aegon, was a huge plot point.
But I think there's still reason for the TV viewers to suspect that Pycelle has something up his sleeve, it's not like Walder Frey was a spry young man when he destroyed the north. He might not end up on the Iron Throne, but he's now the only small council member from Season 1 left on it (Or I don't know if Baelish still is on it), so I wouldn't consider it a minor death at all. Still entirely their responsibility if they want to venture into this thread though.
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