You could easily get to Guadalajara (second largest city in Mexico) from PV for an over-night.
http://en.wikipedia.org/wiki/Guadalajara
Guadalajara is known as La Perla del Occidente (Spanish for "Pearl of the West"), la Perla Tapatía ("tapatío" is an informal adjective of origin for people and things from Guadalajara) and Ciudad de las Rosas (City of the Roses). The city is also the birthplace of mariachi music and charreadas. This beautiful city is considered the "most Mexican" city, and the capital of Jalisco, the "most Mexican" state.