Quote:
Originally Posted by Flames Fan, Ph.D.
2) They reinject a cells of a blood cell lineage (CD34+). What tangible evidence is there that such cells would restore myelin on nerve cells and temper the immune response against the nerves?
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The theory is the CD34+ stem cells then produce and differentiate into CD4+ T cells that no longer are specific for myelin. I think it's far less about the myelin being restored; rather it's the myelin no longer being destroyed by the autoreactive T cells.
This one has promise... I hope. We work on MS in our lab and it's tough to find things that work in mice that work in humans.
ETA: your first point as well - in trials there is no way ethics would ever approve immunosuppression alone in humans.