I have a VERY good friend of mine who is attempting to treat her depression SOLELY with exercise. She has tried seeking professional help in the past, but every doctor that she saw wanted to prescribe medications and each time she found the cure worse than the disease. The side effects of the medications were intolerable. She still has bad days... some VERY bad which worries the hell out of me.... but she tells me that she is much better off now than before starting the exercise regiment.
Of course her biggest worry in the world is getting an injury that would prevent her from exercising. Being injured would impact not only her physical, but also mental health.
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