Disintegrate I think ticks on your attack speed, so greater attack speed will mean the % weapon damage will trigger more often.
Some things like Hydra don't tick faster, but the damage will still scale with attack speed (or so I've read).
What it can do though is like Shawnski be a negative. Higher attack speed will consume resources faster, so if DPS is identical (say between a 1H and 2H weapon) the slower will consume less mana for the same DPS. In the case of a ring with more attack speed, you're trading faster resource consumption for increased DPS, but as he said if you're draining your mana pool anyway then you're just increasing your wait time between shorter spurts of damage.
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