The biggest difficulty in dieting at Mcdonalds would be hunger. All of the fat burns through your 2000 calories very quickly leaving you not many callories to eat with the rest of the day. This makes the diet difficult to sustain and take more willpower then just clean eating.
I think the Calories in Calories out has been proven by looking at various diet plans and they all work about the same. The issue is finding one that you can stick to during the weight loss period and transition you into a sustainable diet long term.
The McDonalds diet is very poor at the two most critical issues.
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